Fluids infused radiofrequency ablation for ground glass nodules in lung; basic and clinical research

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791326
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: MIURA Hiroshi 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (20607593)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ラジオ波焼灼療法 / 肺スリガラス結節

Outline of Final Research Achievements

To access the feasibility of fluids infused radiofrequency ablation (RFA) for pulmonary ground-glass nodules, accumulation and diffusion of fluids in the lung was assessed in lipiodol marking for pulmonary nodules before video-assisted thracoscopic surgery. Lipiodol (0.2ml) was injected with a 21-gauge needle. Size of lipiodol spot obtained was 8.9 mm. Lipiodol was distributed into around structures, however nodular spots were obtained in most cases. Using this technique, RFA with various types of fluids infused was performed on swine with normal lungs. Used fluids were saline, lipiodol and hyaluronic acid. The amount of each fluid was 0.3 ml, respectively. In hyaluronic acid group, coagulation necrosis volume was larger than other groups and hyaluronic acid remained localized. Therefore, hyaluronic acid could be a useful fluid for this method.

Free Research Field

放射線科