Cancer stem cell and radiosensitivity.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: MOTEGI Atsushi 独立行政法人国立がん研究センター, 東病院, 医員 (10433997)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線感受性 / 中咽頭癌 / がん幹細胞マーカー / CD44 / p16 / HPV

Outline of Final Research Achievements

To elucidate the correlation between cancer-stem-cell marker expression and tumor radiosensitivity, immunohistochemical analysis in head and neck cancer was performed. Expression of cancer-stem-cell marker CD44 and p16, the surrogate marker of HPV infection, in oropharyngeal cancer were investigated retrospectively. The impact of protein expressions on treatment outcomes were also investigated. The loco-regional control rates of the patient with CD44 expression was significantly worse than those without CD44 expression. And moreover, the combined analysis of CD44 and p16 showed that patients with CD44 negative and p16 positive expression had the best treatment outcomes, and those with CD44 positive and p16 negative expression had the worst treatment outcomes. This result might indicate that cause of tumorigenesis can affect cancer-stem-cell marker expression in oropharyngeal cancer.

Free Research Field

放射線腫瘍学