2015 Fiscal Year Final Research Report
Intra-arterial infusion of thrombin: animal experiments
| Project/Area Number |
24791344
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
INOUE Michito
KOMEMUSHI Sadao
KARIYA Shuji
TANIGAWA Noboru
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | IVR / DDS / 低侵襲治療 / Interventional Radiology / 放射線医学 / Oncology / 化学療法 |
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| Outline of Final Research Achievements |
The platinum concentrations in plasma in 5 and 10 minutes after administration were 0.59±0.28μg/ml and 0.70±0.078μg/ml for the thrombin group, respectively, and 2.7±1.2μg/ml and 2.2±0.58μg/ml for the control group, respectively. At both 5 and 10 min after infusion, the platinum concentrations in plasma for the thrombin group were significant lower than that for the control group.
The platinum concentration in tumor tissue was 4.1±1.8 μg/wet・g for the thrombin group and 1.0±1.2μg/wet・g for the control group. The platinum concentration in tumor tissue for the thrombin group was significantly higher than that for the control group.
The present results suggest that transarterial infusion with thrombin may have a number of pharmacological advantages.
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| Free Research Field |
低侵襲治療
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