Optimization of Iodine and Radiation Dosage in Hepatic Dynamic CT

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kinki University
• Principal Investigator: HYODO Tomoko 近畿大学, 医学部, 講師 (40403836)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: デュアルエナジーCT / dual-energy CT / ヨード造影剤 / ダイナミックCT / 肝臓 / 逐次近似法 / 低侵襲 / 画像診断

Outline of Final Research Achievements

As a clinical relevance of this study, virtual monochromatic image (VMI) reconstruction at lower keV In dual-energy CT (DECT) imaging allow reduction in iodine dose, which can contribute the reduction of risk of contrast-induced nephropathy. We aimed to validate a protocol with reduced iodine load for hepatic dynamic CT using VMI. We firstly conducted a phantom experiment to determine an optimal iodine load, 30% reduction in dose, and ASiR level for VMI at 60keV (protocol A). Then we conducted a clinical study in which 54 patients suspected of liver diseases underwent three-phase dynamic CT with protocol A and the other 54 patients underwent full iodine load with single-energy CT (protocol B). The clinical study showed that no significant difference in any of the CT attenuation values between protocols A and B. In conclusion, VMIs allows 30% reduction of iodine load while maintaining comparable image quality to full iodine load with the SECT imaging.

Free Research Field

肝臓の画像診断