PET measurements of interaction between glutamatergic and dopaminergic neurons

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791352
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: KIMURA Yasuyuki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (20423171)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 代謝型グルタミン酸受容体サブタイプ 5 / ポジトロンエミッショントモグラフィー / reproducibility

Outline of Final Research Achievements

To establish a method to quantify density of metabotropic glutamate receptor subtype 5 in human brain, which is related to the interaction between glutamatergic and dopaminergic neurons, we evaluated a new PET ligand, 11C-(E)ABP688, in healthy volunteers as a test-retest study in a same day. As results, distribution volume of 11C-(E)ABP688 was well estimated, and its regional distribution was consistent with the know distribution of the receptor. However, its reproducibility was poor that 30% decrease in the distribution volume was observed in the afternoon compared to in the morning.

Free Research Field

脳神経核医学