2014 Fiscal Year Final Research Report
Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis
| Project/Area Number |
24791370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 移植後動脈硬化 / 慢性拒絶 / ムスカリン性ACh受容体 |
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| Outline of Final Research Achievements |
We investigated the role of muscarinic acetylcholine receptor (mAChR) in the development of transplant arteriosclerosis. Fully major histocompatibility complex-mismatched donor hearts were transplanted into mAChR-KO recipient mice. There were no differences in heart graft survival between the wild-type and mAChR-KO recipients. Using the same strain combination, orthotopic carotid artery allotransplantation was performed. There was no difference in the development of transplant arteriosclerosis between the groups. However, when a minor histocompatibility antigen-mismatched strain combination was used, the development of transplant arteriosclerosis was significantly reduced in the mAChR-KO recipients. These results suggest that mAChR may play an important role in the development of transplant arteriosclerosis.
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| Free Research Field |
医歯薬学
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