2013 Fiscal Year Final Research Report
The identification of HLA class II DR associated molecules contributing to Accommodation
| Project/Area Number |
24791371
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
IWASAKI Kenta 名古屋大学, 医学(系)研究科(研究院), 寄附講座講師 (10508881)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 免疫順応 / シグナル伝達 / 抗体関連型拒絶反応 |
|---|
| Research Abstract |
Expression of HLA-DR on endothelial cells was elicited by IFNg treatment. HLA class I expression was also increased about 4-5 fold. When treated with IFNg, anti-HLA class I and DR antibody binding to endothelial cells did not show any cytoprotective effect against complement-mediated cytotoxicity (CDC) and activated AKT signal, while pre-incubation with anti-A antibody habe resistance to CDC. Anti-HLA class II DR IgG antibody purified from patient sera decreased CD59 expression.
|
