Nogo-B controls vascular remodeling

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791372
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Mie University
• Principal Investigator: KONDO Yuka 三重大学, 医学部附属病院, 診療従事者等 (90440677)
• Research Collaborator: MUTO Akihito ; SHIMPO Hideto ; DARDIK Alan
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 静脈グラフト / リモデリング

Outline of Final Research Achievements

Objective: Recent work has demonstrated that Nogo-B mediates vascular protection and may facilitate macrophage-driven vascular remodeling. PirB is an alternate receptor for Nogo-B. We examined whether PirB may play a role in regulating macrophage-mediated vascular remodeling and hypothesized that endothelial Nogo-B may regulate vein graft macrophage traffic via its alternate receptor PirB.
Conclusions: Vein graft adaptation shows increased expression of both Nogo-B and PirB. Loss of PirB, or its endothelial ligand Nogo-B, results in increased inflammatory cell infiltration and vein graft wall thickening. These findings suggest that PirB is a regulator of macrophage activity in vein grafts and that Nogo-B in the vein graft limits macrophage infiltration and vein graft thickening. Macrophage inhibition via Nogo-PirB interactions may be an important mechanism regulating vein graft adaptation to the arterial circulation.

Free Research Field

血管外科