2013 Fiscal Year Final Research Report
The role of calpain on the development of abdominal aortic aneurysm
| Project/Area Number |
24791376
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
UCHIDA Haruhito 岡山大学, 医歯(薬)学総合研究科, 助教 (00550857)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 血管外科学 / 大動脈瘤 |
|---|
| Research Abstract |
We examined the effect of calpain on the development of abdominal aortic aneurysm using AngII-infused apolipoprotein E deficient (apoE -/-) mice model.
First, a calpain inhibitor significantly attenuated the formation of abdominal aortic aneurysm. On the other hand, calpain-1 deficiency in apoE -/- mice had no effect on the development of abdominal aortic aneurysm. Therefore, we found the significance of calpain on the development of abdominal aortic aneurysm however, it still remains unknown which isoform of calpain is important.
|
