2013 Fiscal Year Final Research Report
Novel diagnostic and therapeutic method using genomic instability of breast cancer.
| Project/Area Number |
24791382
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | National Hospital Organization, Kyushu Cancer Center (2013)
Nagasaki University (2012) |
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Principal Investigator |
OIKAWA Masahiro 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 乳腺科フェロー (90612416)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ゲノム不安定性 / 乳癌 / アレイCGH / 染色体構造変化 / 腫瘍内不均一性 |
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| Research Abstract |
High risk patients among ER-positive/HER2-negative breast cancer can be stratified by intra-tumoral heterogeneity as a surrogate marker for genomic instability. The double-stranded DNA ratio of tumor DNA predicted the performance of DNA from FFPE samples on the aCGH analysis. Quality control by this metrics can utilize valuable FFPE archival tissue on aCGH analysis. our novel diagnostic method, which targets genomic instability, can clearly distinguish cancers from benign tumors of breast intracystic lesions with minimum invasion, thereby avoiding the need for surgical excisional biopsy. Novel therapeutic strategy targeting genomic instability in breast cancer, which is dual administration of Olaparib and Gimeracil, showed growth inhibition of breast cancer cell line with high genomic instability.
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[Journal Article] Novel diagnostic procedure for determining metastasis to sentinel lymph nodes in breast cancer using a semi-dry dot-blot (SDB) method2014
Author(s)
Otsubo R, Oikawa M, Hirakawa H, Shibata K, Abe K, Hayashi T, Kinoshita N, Shigematsu K, Hatachi T, Yano H, Matsumoto M, Takagi K, Tsuchiya T, Tomoshige K, Nakashima M, Taniguchi H, Omagari T, Itoyanagi N, Nagayasu T
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Journal Title
IJC
Volume: 134(4)
Pages: 905-912
Peer Reviewed
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[Journal Article] A predictive factor of microarray comparative genomic hybridization analysis quality for formalin-fixed paraffin-embedded archival tissue2013
Author(s)
Nakao K, Oikawa M, Arai J, Mussazhanova Z, Kondo H, Shichijo K, Nakashima M, Hayashi T, Yoshiura K, Hatachi T, Nagayasu T
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Journal Title
Diagn Mol Pathol
Volume: 22(3)
Pages: 174-180
Peer Reviewed
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[Journal Article] Clinical and molecular analysis of synchronous double lung cancers2012
Author(s)
Arai J, Tsuchiya T, Oikawa M, Mochinaga K, Hayashi T, Yoshiura K, Tsukamoto K, Yamasaki N, Matsumoto K, Miyazaki T, Nagayasu T
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Journal Title
Lung Cancer
Volume: 77(2)
Pages: 281-7
Peer Reviewed
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[Presentation] The impact of intra-tumoral heterogeneity on the prognosis of ER-positive/HER2-negative breast cancer2014
Author(s)
Oikawa M, Ishida M, Nakamura Y, Nishimura S, Koga C, Saruwatari A, Igawa A, Akiyoshi S, Koi Y, Ohno S
Organizer
ASCO2014
Place of Presentation
シカゴ, 米国
Year and Date
20140530-0603
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[Presentation] 乳腺嚢胞内腫瘍に対する, ゲノム不安定性を指標にした良悪性鑑別法の検討2013
Author(s)
及川将弘, 矢野洋, 松本恵, 大坪竜太, 林徳真吉, 安倍邦子, 木下直江, 黒木祥司, 及川達司, 永安武
Organizer
第113回日本外科学会定期学術集会
Place of Presentation
福岡
Year and Date
20130411-13
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[Presentation] 乳癌FFPE 標本を用いたアレイCGH 解析の精度管理2012
Author(s)
及川将弘, 中尾健次郎, 柴田健一郎, 松本恵, 矢野洋, 木下直江, 安倍邦子, 林徳真吉, 蔵重智美, 三浦史郎, 中島正洋, 永安武
Organizer
第20回日本乳癌学会学術総会
Place of Presentation
熊本
Year and Date
20120628-30
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