2014 Fiscal Year Final Research Report
The effectiveness of the newly antioxidant for radiation enteritis, dermatitis
| Project/Area Number |
24791386
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 外科 / 放射線 |
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| Outline of Final Research Achievements |
The therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation enterocolitis model was created by irradiation of rats with a single dose of 10 Gy. ETS-GS was administered subcutaneously (10 mg/kg/day) for five consecutive days from two days prior to irradiation. The ileal mucous membrane disorder of the ETS-GS administrated group was controlled in comparison with radiation exposure that received no ETS-GS group. In the ETS-GS administrated group, various inflammatory and oxidative stress markers were significantly lower than radiation exposure alone group. In this study, ETS-GS with antioxidant activity has a therapeutic effect on the symptoms of radiation enterocolitis in a rat model. Subsequently, the effectiveness of the ETS-GS for radiation dermatitis model is planned to study.
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| Free Research Field |
医歯薬学
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