2014 Fiscal Year Final Research Report
Investigation of cancer vaccine therapy with novel immune-adjuvant for the patient with esophageal cancer
| Project/Area Number |
24791390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | がんワクチン / アジュバント / 食道癌 |
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| Outline of Final Research Achievements |
We have developed new adjuvants useful in vaccine therapy for cancer patients, and we searched the usefulness of HVJ-E, which co-stimulate the RIG-I / TLR-8, as one of the candidates for an adjuvant to enhance the effect of cancer peptide vaccine. It was revealed that the HVJ-E induced the production of inflammatory cytokines such as IL-17, IFN, IL-6 and TNF through the maturation and activation of dendritic cells. On the other hand, producing these cytokines in the systemic was suggested to inhibit the anti-tumor immune responses. In addition, we have started a new clinical study of peptides vaccine for the patients of esophageal cancer. So far, 22 patients were enrolled and we have started immunologic assessment of peptide-specific activated CTL (ELISPOT testing, multimer assay). By storing this new but basic data, we are preparing to initiate a next clinical study of cancer peptides vaccine in combination with a novel immune adjuvant.
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| Free Research Field |
消化器外科学
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