Mesenchymal Stem Cell transplantation for Reconstruction of Breast Cancer patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791392
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Keio University
• Principal Investigator: SEKI Tomoko 慶應義塾大学, 医学部, 助教 (70528900)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 幹細胞 / 乳房再建 / 細胞移植 / 組織工学

Outline of Final Research Achievements

This study was to investigate new strategy for the reconstruction of mammary gland after glandectomy for breast cancer patients using autologous mesenchymal stem cell transplantation with self absorbable hydrogel. The mouse model we used was an unique model generated by resecting mammary fat pad which is the immature breast tissue in mouse and mimicking the patients who suffered partial breast resection. The result of the transplantation of human mesenchymal stem cell demonstrated that the cells could sufficiently restore the space after the fat pad resection in mouse and showed no tumorigenesis or inflammatory response. Therefore, we assume that this new strategy using autologous mesenchymal stem cell for the reconstruction of the breast will be one of the options for breast cancer patient without surgical incision.

Free Research Field

乳腺外科