2013 Fiscal Year Final Research Report
Subtype-specific metabolic characteristics and tailor-made treatment strategy in breast cancer by metabolome analysis
| Project/Area Number |
24791394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 乳癌 / メタボローム解析 / MALDI-MS |
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| Research Abstract |
Currently treatments are decided based on subtypes in breast cancer, however, metabolic alterations of subtypes remain to be elucidated.
Here, we analyzed subtype-specific metabolic alterations by using clinical specimens and cell lines of breast cancer. The most different metabolic characteristics were observed between luminal and triple negative type when we analyzed aspiration biopsy specimens by CE-MS. We also prepared tumor tissue which was obtained from transplanting cell lines of human breast cancer into immunodeficient mouse. As a result, we revealed distinctive metabolic patterns according to subtypes when we use MALDI-IMS.
Our results provided novel insights into tailor-made treatment for breast cancer using metabolome analysis by the leading edge of measurement technology.
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