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2013 Fiscal Year Final Research Report

Impaired Angiogenesis During Hindlimb Ischemia in Skeletal Muscle-Specific STAT3 Deficient Mice

Research Project

  • PDF
Project/Area Number 24791397
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKurume University

Principal Investigator

OHSHIMA Hideki  久留米大学, 医学部, 助教 (90569419)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords下肢虚血 / 血管新生 / サイトカイン / Jak-STAT
Research Abstract

Although the STAT3 activating cytokines play an important role in angiogenesis, little is known about the STAT3 role in skeletal muscle during ischemia-induced angiogenesis. STAT3 was promptly phosphorylated within skeletal muscle, and STAT3-activating cytokine including interleukin-6 and G-CSF were increased during hindlimb ischemia (HLI). Blood-flow recovery after HLI was impaired in skeletal muscle-specific, STAT3 knockout mice (sm-STAT3-KO). The number of CD31 positive cells after HLI was significantly less in sm-STAT3-KO than that in wild-type mice. Real-time PCR array analysis for angiogenesis revealed that the expression levels of angiogenic chemokines and inflammatory cytokines were significantly much lower in sm-STAT3-KO than those in wild-type mice after HLI. These results suggested that angiogenesis during ischemia was impaired in sm-STAT3-KO, possibly through the inhibition of angiogenic chemokines and inflammatory cytokines expression.

  • Research Products

    (12 results)

All 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (2 results)

  • [Journal Article] Screening for Fabry disease in patients with left ventricular hypertrophy2013

    • Author(s)
      Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sakubaba H, Imaizumi T
    • Journal Title

      Int J Cardiol

      Volume: 167 Pages: 1059-1061

    • Peer Reviewed
  • [Journal Article] Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction2012

    • Author(s)
      Oba T, Yasukawa H, Hoshijima M, Sasaki KI, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T
    • Journal Title

      J Am Coll Cardiol

      Volume: 59 Pages: 838-852

    • Peer Reviewed
  • [Journal Article] Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice2012

    • Author(s)
      Ohmura H, Yasukawa H, Minami T, Sugi Y, Oba T, Nagata T, Kyougoku S, Ohshima H, Aoki H, Imaizumi T
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 1063-1068

    • Peer Reviewed
  • [Presentation] Screening for Fabry Disease in Patients with Left Ventricular Hypertrophy2013

    • Author(s)
      Mawatari K, Yasukawa H, Oba T, Nagata T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Imaizumi T
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      埼玉
    • Year and Date
      20131128-30
  • [Presentation] Cardiac-Specific Deletion of Suppressor of Cytokine Signaling-3 Prevents Doxorubicin-Induced Cardiomyopathy in Mice.The American Heart Association2012

    • Author(s)
      Kyogoku S, Yasukawa H, Nagata T, Oba T, Ohshima H, Minami T, Yajima T, Hoshijima M, Aoki H, Knowlton KU, Imaizumi T
    • Organizer
      The 85th Scientific Sessions
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      20121103-07
  • [Presentation] Pioglitazone Decreases Plasma Fibroblast Growth Factor-21 Levels in Patients with Type 2 Diabetes. The American Heart Association2012

    • Author(s)
      Mawatari K, Tahara N, Yasukawa H, Oba T, Nagata T, Kyougoku S, Ohshima H, Minami T, Mizoguchi M, Sugi Y, Adachi H, Imaizumi T
    • Organizer
      The 85th Scientific Sessions
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      20121103-07
  • [Presentation] Prevention of Doxorubicin-Induced Cardiomyopathy in Cardiac-Specific SOCS3 Deficient Mice by Preserving Energy Metabolism2012

    • Author(s)
      Kyogoku S, Yasukawa H, Nagata T, Oba T, Ohshima H, Minami T, Fukui D, Sugi Y, Aoki H, Imaizumi T
    • Organizer
      第29回 国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      福岡
    • Year and Date
      20121026-27
  • [Presentation] Impaired Angiogenesis During Hindlimb Ischemia in Skeletal Muscle-Specific STAT3 Deficient Mice2012

    • Author(s)
      Ohshima H, Yasukawa H, Nagata T, Kyogoku S, Oba T, Mawatari K, Futamata N, Minami T, Sugi Y, Sasaki K, Imaizumi T
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      20120316-18
  • [Presentation] Prevention of Left Ventricular Remodeling after Acute Myocardial Infarction in Interleukin-17 Deficient Mice2012

    • Author(s)
      Minami T, Yasukawa H, Nagata T, Oba T, Kyogoku S, Ohshima H, Aoki H, Yoshimura A, Imaizumi T
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      20120316-18
  • [Presentation] Pioglitazone Decreases Plasma Fibroblast Growth Factor-21 Levels in Patients with Type 2 Diabetes2012

    • Author(s)
      馬渡一寿, 田原宣広, 安川秀雄, 大場豊治, 二又誠義, 永田隆信, 京極幸子, 大島英樹, 南知子, 溝口ミノリ, 足達寿, 今泉勉
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      20120316-18
  • [Remarks]

    • URL

      http://www.kurume-shinzo.com

  • [Remarks]

    • URL

      http://www.med.kurume-u.ac.jp/med/kucri/

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Published: 2015-06-25   Modified: 2015-08-05  

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