2014 Fiscal Year Final Research Report
Analysis of the relationships between migration and differentiation of regulatory T cells and helper T-17 cells and cancer staging in the esophageal cancer.
| Project/Area Number |
24791404
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 制御性T細胞 / 癌微小環境 / 過酸化水素 / 活性酸素 / アポトーシス / 癌免疫治療 |
|---|
| Outline of Final Research Achievements |
An increase in regulatory T cells (Tregs) is observed in tumor microenvironments. Since it was suggested that Tregs showed a lower sensitivity toward oxidative stress in comparison with conventional T cells (Tcon), we investigated the H(2)O(2) production and apoptosis of Tregs in esophageal cancer tissues, employing flow cytometric analysis and immunohistochemical analysis. The increased tumor-infiltrating Tregs coexisted with elevated H(2)O(2) production according to disease progression. The grade of apoptosis in Tregs was less pronounced than that in Tcon, and there was a positive correlation between H(2)O(2) production and the grade of apoptosis in Tcon, while there was no correlation between H(2)O(2) production and the grade of apoptosis in Tregs. Moreover, Tregs were less sensitive to H(2)O(2)-induced apoptosis compared with Tcon in vitro. As conclusions, the increased prevalence of tumor-infiltrating Tregs closely related to their lower sensitivity to H(2)O(2)-induced apoptosis.
|
| Free Research Field |
食道外科学
|
