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2013 Fiscal Year Final Research Report

study about a novel elucidation of endoplasmic reticulum stress response on ischemia/reperfusion injury and liver regeneration after massive hepatectomy and living donor liver transplantation

Research Project

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Project/Area Number 24791426
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

MORI Hiroki  徳島大学, 大学病院, 助教 (70448330)

Research Collaborator ISHIBASHI Hiroki  徳島大学, 大学病院, 講師 (20314867)
UTSUNOMIYA Tohru  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30304801)
IMURA Satoru  徳島大学, 大学病院, 助教 (30304801)
MORINE Yuji  徳島大学, 大学病院, 助教 (60398021)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords大量肝切除 / 肝再生 / 小胞体ストレス応答
Research Abstract

It is important issue to overcome liver failure after extended hepatectomy (Hx) or living donor liver transplantation which is still serious problem. This time, we investigated the involvement of the endoplasmic reticulum stress response on liver regeneration, using 70% Hx model, postoperative liver regeneration model, and 90% Hx model, postoperative liver failure model. In 90% Hx model, mRNA of intrahepatic endoplasmic reticulum stress response related genes were time-dependently up-regulated up to maximum 6 times at 1, 3, 7, 14, 21 days after Hx. In addition, they were strongly expressed since the late phase after postoperative 7 days. In 70% Hx model, they were time-dependently up-regulated up to about 1.5 to 3 times but not strongly expressed in equivalent to liver failure model.

  • Research Products

    (22 results)

All 2014 2013 2012

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (8 results)

  • [Journal Article] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through the epigenetic regulation2014

    • Author(s)
      Mori H, Ishibashi H, Shimada M, Utsunomiya T, Asanoma M, Yamada S, Saito Y, Iwahashi S, Ikemoto T, Imura S, Morine Y
    • Journal Title

      Hepatogastroenterology

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats2014

    • Author(s)
      Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 692-701

    • DOI

      10.1007/s00535-013-0799-9

    • Peer Reviewed
  • [Journal Article] Changes of immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto / TJ-48) in patients with advanced pancreatic cancer2014

    • Author(s)
      Ikemoto T, Shimada M, Iwahashi S, Saito Y, Kanamoto M, Mori H, Morine Y, Imura S, Utsunomiya T
    • Journal Title

      Int J Clin Oncol

      Volume: 19 Pages: 81-86

    • DOI

      10.1007/s10147-013-0529-6

    • Peer Reviewed
  • [Journal Article] CXC receptor 4 and stromal cell-derived factor 1 in primary tumors and liver metastases of colorectal cancer2014

    • Author(s)
      Yamada S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y
    • Journal Title

      J Surg Res

      Volume: 187 Pages: 107-112

    • DOI

      10.1016/j.jss.2013.10.030

    • Peer Reviewed
  • [Journal Article] Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver2014

    • Author(s)
      Hanaoka J, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Sugimoto K, Saito Y, Yamada S, Asanoma M
    • Journal Title

      Hepatol Res

      Volume: 44 Pages: 114-121

    • DOI

      10.1111/hepr.12097.

    • Peer Reviewed
  • [Journal Article] Iliopsoas Abscess in an Infant2014

    • Author(s)
      Ishibashi H, Oshio T, Sogami T, Nii A, Mori H, Yada K, Shimada M
    • Journal Title

      J Med Invest

      Volume: 61 Pages: 213-216

    • Peer Reviewed
  • [Journal Article] Dye-assisted lymphatic sparing laparoscopic Palomo varicocelectomy in children2014

    • Author(s)
      Ishibashi H, Mori H, Yada K, Shimada M, Sogami T, Nii A
    • Journal Title

      J Med Invest

      Volume: 61 Pages: 151-155

    • Peer Reviewed
  • [Journal Article] TheraCyte^<TM> device protects against islet allograft rejection in immunized hosts2013

    • Author(s)
      Kumagai-Braesch M, Jacobson S, Mori H, Jia X, Takahashi T, Wernerson A, Flodström-Tullberg M, Tibell A
    • Journal Title

      Cell Transplant

      Volume: 22 Pages: 1137-1146

    • DOI

      10.3727/096368912X657486

    • Peer Reviewed
  • [Journal Article] The protective effect of adipose-derived stem cells against liver injury by trophic molecules2013

    • Author(s)
      Saito Y, Shimada M, Utsunomiya T, Ikemoto T, Yamada S, Morine Y, Imura S, Mori H, Sugimoto K, Iwahashi S, Asanoma M
    • Journal Title

      J Surg Res

      Volume: 180 Pages: 162-168

    • DOI

      10.1016/j.jss.2012.10.009

    • Peer Reviewed
  • [Journal Article] Significance of sonic hedgehog signaling after massive hepatectomy in a rat2013

    • Author(s)
      Hanaoka J, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H
    • Journal Title

      Surg Today

      Volume: 43 Pages: 300-307

    • DOI

      10.1007/s00595-012-0248-z

    • Peer Reviewed
  • [Journal Article] Indoleamine 2, 3- dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood2013

    • Author(s)
      Ikemoto T, Shimada M, Komatsu M, Yamada S, Saito Y, Mori H, Morine Y, Imura S, Bando Y, Utsunomiya T
    • Journal Title

      Pancreas

      Volume: 42 Pages: 130-134

    • DOI

      10.1097/MPA.0b013e3182575e4a

    • Peer Reviewed
  • [Journal Article] The impact of pegylated-interferon α-2b on partial and massive hepatectomy model in rats2012

    • Author(s)
      Mori H, Shimada M, Ikegami T, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Hanaoka J, Iwahashi S, Saito Y, Asanoma M, Yamada S, Miyake H
    • Journal Title

      Hepatogastroenterology

      Volume: 59 Pages: 2300-2304

    • DOI

      10.5754/hge10401

    • Peer Reviewed
  • [Journal Article] Impact of a new refrigerator on the preservation of hepatic grafts2012

    • Author(s)
      Kanamoto M, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 798-805

    • DOI

      10.1111/j.1872-034X.2012.00987.x

    • Peer Reviewed
  • [Journal Article] Role of histone deacetylase expression in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Miyake H
    • Journal Title

      Surgery

      Volume: 151 Pages: 412-419

    • DOI

      10.1016/j.surg.2011.07.038

    • Peer Reviewed
  • [Presentation] Risk of carcinogenesis in the biliary epithelium in patients with pancreaticobiliary maljunction through both epigenetic and genetic regulation2013

    • Author(s)
      Mori H, Ishibashi H, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Yada K, Shimada M
    • Organizer
      International Surgical Week (ISW 2013)
    • Place of Presentation
      フィンランド(Helsinki Exhibition and Convention Centre)
    • Year and Date
      20130825-29
  • [Presentation] 膵・胆管合流異常症に対する長期経過中に胆道癌を合併した3 症例の検討2013

    • Author(s)
      森大樹, 島田光生, 石橋広樹, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎県(シーガイアコンベンションセンター)
    • Year and Date
      20130717-19
  • [Presentation] 分子標薬的Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果2013

    • Author(s)
      森大樹, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 山田眞一郎, 淺野間理仁, 石川大地, 三宅秀則
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      20130606-07
  • [Presentation] ラットの膵・胆管合流異常症モデルの意義と課題2013

    • Author(s)
      森大樹, 石橋広樹, 佐藤宏彦, 矢田圭吾, 島田光生
    • Organizer
      第50回日本小児外科学会学術集会
    • Place of Presentation
      東京都(京王プラザホテル)
    • Year and Date
      20130530-0601
  • [Presentation] 胆道癌発がんモデルの膵・胆管合流異常症での発がん特性の解析2013

    • Author(s)
      森大樹, 島田光生, 宇都宮徹, 石橋広樹, 佐藤宏彦, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 矢田圭吾, 淺野間理仁, 山田眞一郎, 石川大地, 三宅秀則
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡県(マリンメッセ福岡)
    • Year and Date
      20130411-13
  • [Presentation] 分子標的薬Bevacizumab の小胞体ストレス応答を介した肝切除後肝機能障害改善効果2012

    • Author(s)
      宮谷智彦, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 森大樹, 花岡潤, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎, 三宅秀則
    • Organizer
      日本消化器関連学会週間【第10回日本消化器外科学会】
    • Place of Presentation
      兵庫県(神戸国際会議場)
    • Year and Date
      20121010-13
  • [Presentation] Bevacizumab は小胞体ストレス応答を介して肝切除後肝機能障害を改善する2012

    • Author(s)
      徳永卓哉, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 森大樹, 花岡潤, 杉本光司, 齋藤裕, 浅野間理仁, 山田眞一郎, 三宅秀則
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉県(幕張メッセ)
    • Year and Date
      20120412-14
  • [Presentation] Bevacizumab の小胞体ストレス応答を介した大量肝切除後肝機能障害改善・肝再生促進効果2012

    • Author(s)
      森大樹, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 浅野間理仁, 山田眞一郎, 石川大地, 三宅秀則
    • Organizer
      第19回外科侵襲とサイトカイン研究会
    • Place of Presentation
      兵庫県(ホテルオークラ神戸)
    • Year and Date
      2012-12-08

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Published: 2015-06-25  

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