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2013 Fiscal Year Final Research Report

Elucidation of the radioresistance mechanism on the microenviroment of pancreatic cancer and control of the stroma cells causing radioresistance by newly artificial virus.

Research Project

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Project/Area Number 24791431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

ONIMARU Manabu  九州大学, 医学(系)研究科(研究院), 共同研究員 (80529876)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords膵癌 / HDAC1 / DNA / Double Strand Break / Trichostatin A / iRNA
Research Abstract

Pancreatic ductal adenocarcinoma (PDA) is characterised by aggressive tumor spread, early metastasis and a poor prognosis. Standard therapy for PDA patients includes not only surgery and chemotherapy but also radiotherapy. However, there have been few detailed molecular biological studies to investigate about the effect of radiotherapy on PDA. It was reported that histone deacetylase 1 (HDAC1) is responsible for DNA repair of double strand breaks after irradiation in human fibroblasts. Here, we examined HDAC1 is involved in the mechanism of radioresistance of PDA. The irradiated pancreatic cancer cell lines reduced the radiosensitivity and increased the HDAC1 mRNA expression. The radioresistance was decreased after the addition of low-concentration TSA or knockdown of HDAC1 in pancreatic cancer cell lines. The present data suggested that HDAC1 is invoved in the mechanism of the radioresistance of pancreatic cancer cells.

  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 膵癌細胞株におけるHiston deacetylase 1の放射線耐性に関する評価2013

    • Author(s)
      田中友晴, 小薗真吾, 大内田研宙, 水元一博, 田中雅夫
    • Organizer
      日本外科学会総会
    • Place of Presentation
      九州大学 臨床・腫瘍外科
    • Year and Date
      20130400
  • [Presentation] Histon deacetylase 1 is responsible for radioresistance of pancreatic cancer cells2013

    • Author(s)
      Tomoharu Tanaka, Shingo Kozono, Kenoki Ohuchida, Kazuhiro Mizumoto and Masao Tanaka
    • Organizer
      American Pancreatic Association
    • Place of Presentation
      Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
    • Year and Date
      20130000

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Published: 2015-06-25  

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