The elucidation of IL-17/IL-21 axis and new immunotherapy in tumor microenvironment

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791446
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: IIDA Takeshi 和歌山県立医科大学, 医学部, 学内助教 (30453187)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 胃癌 / 腫瘍 / IL-17 / 腹腔

Research Abstract

We investigated the expression level of IL-17 mRNA in peritoneal lavage with gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. IL-17 mRNA expression was associated with the depth of the invasion.The survival curves in patients who underwent curative resection showing high expression of IL-17 mRNA were significantly better than that in patients showing low expression of IL-17 mRNA. In a multivariate analysis, IL-17 mRNA-low expression in peritoneal lavage and tumor size were independent significant predictive factors for prognosis.IL-17 mRNA expression in peritoneal lavage detected by real-time RT-PCR is a reliable prognostic factor in patients with curative resection in gastric cancer. Low IL-17 gene expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.

Research Products

• [Journal Article] Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection (2014)
  • Author(s): Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Yasuoka H, Yamaue H
  • Journal Title: Oncol Rep Volume: 31(2) Pages: 605-12
  • Peer Reviewed
• [Journal Article] Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells : in comparison to bone marrow-derived DCs (2014)
  • Author(s): Iwamoto H, Ojima T, Hayata K, Katsuda M, Miyazawa M, Iida T, Nakamura M, Nakamori M, Iwahashi M, Yamaue H
  • Journal Title: Int J Cancer Volume: 134(2) Pages: 332-41
  • Peer Reviewed
• [Journal Article] Inhibition of IL-17A in tumor microenvironment augments cytotoxicity of tumor-infiltrating lymphocytes in tumor-bearing mice (2013)
  • Author(s): Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T, Yamaue H
  • Journal Title: PLoS One Volume: 8(1) Pages: e53131
  • Peer Reviewed
• [Journal Article] An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer (2013)
  • Author(s): Tsuji T, Nakamori M, Iwahashi M, Nakamura M, Ojima T, Iida T, Katsuda M, Hayata K, Ino Y, Todo T, Yamaue H
  • Journal Title: Int J Cancer Volume: 132(2) Pages: 485-94
  • Peer Reviewed
• [Presentation] 胃癌腹腔洗浄液中におけるIL-17mRNA の発現解析 (2013)
  • Author(s): 飯田武, 岩橋誠, 勝田将裕, 中森幹人, 中村公紀, 尾島敏康, 辻 俊明, 早田啓治, 松村修一, 加藤智也, 川井学, 谷眞至, 瀧藤克也, 山上裕機
  • Organizer: 第113回日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20130400