2013 Fiscal Year Final Research Report
Analysis of immunoglobulins reactive to CTL epitopes peptides
| Project/Area Number |
24791452
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kurume University |
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Principal Investigator |
MATSUEDA Satoko 久留米大学, がんワクチンセンター, 講師 (60610582)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 抗ペプチド抗体 / がん / ペプチド / 生命予後 / バイオマーカー / 腫瘍関連抗原 |
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| Research Abstract |
We assessed immunoglobulins reactive to CTL epitopes peptides derived from tumor-associated antigens in healthy donors and cancer patients. The sum of immunoglobulins reactive CTL epitopes peptides were well correlated with better overall survival in cancer patients. Our results suggested that measurement of immunoglobulins specific to CTL epitope peptides may provide a new biomarker for overall survival of patients with cancer. From this analysis of anti-peptide antibodies in vitro and vivo, we found that immunoglobulins specific to CTL epitope peptide may play a roll to enhance and induce tumor antigen specific cytotoxic T cells.
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[Journal Article] Humoral immune responses to CTL epitope peptides from tumor-associated antigens are widely detectable in humans : a new biomarker for overall survival of patients with malignant diseases2013
Author(s)
Matsueda S, Komatsu N, Kusumoto K, Koga S, Yamada A, Kuromatsu R, Yamada S, Seki R, Yutani S, Shichijo S, Mine T, Fukuda T, Okamura T, Okuda S, Sata M, Honda J, Kaji M, Itoh K, Sasada T
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Journal Title
Dev Comp Immunol
Volume: 41(1)
Pages: 68-76
DOI
Peer Reviewed
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