Infection Resistant Prosthetic Vascular Graft

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791458
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Nagoya University
• Principal Investigator: TOKUDA Yoshiyuki 名古屋大学, 医学部附属病院, 病院助教 (30467302)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 人工血管感染

Research Abstract

Using bio-absorbable polymer coating, we created prosthetic vascular graft which could constantly release antibiotics. After numerous trials, we found the drug eluting grafts created were generally fragile and thick, and not fit for vascular anastomosis. Instead, conventional rifampicin-soaked graft was rather effective for the treatment of graft infection if diagnosis was obtained promptly. We found FDG-PET was a very useful diagnostic tool for distinguishing graft infection. The present research revealed new treatment strategy of prosthetic vascular graft infection.

Research Products

• [Journal Article] Detection of thoracic aortic prosthetic graft infection with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (2013)
  • Author(s): Tokuda Y, Oshima H, Araki Y, Narita Y, Mutsuga M, Kato K, Usui A
  • Journal Title: Eur J Cardiothorac Surg Volume: 43(6) Pages: 1183-7
  • Peer Reviewed
• [Presentation] 心臓血管外科領域の難治感染症に対するFDG-PET/CT の応用 (2014)
  • Author(s): 徳田順之, 大島英揮, 阿部知伸, 成田裕司, 荒木善盛, 藤本和朗, 六鹿雅登, 寺澤幸枝,蒔苗永, 松村泰基, 伊藤英樹, 八神啓, 大野司, 末永啓人, 碓氷章彦
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館, グランドプリンスホテル京都京都市
  • Year and Date: 2014-04-05
• [Presentation] 胸部下行大動脈瘤置換術後の遷延する発熱の一例 (2013)
  • Author(s): 徳田順之, 末永啓人, 蒔苗永, 岡田典隆, 野中利通, 岡田正穂, 薦田さつき, 六鹿雅登, 藤本和朗, 荒木善盛, 成田裕司, 大島英揮, 碓氷章彦
  • Organizer: 第98回東海心臓外科懇話会
  • Place of Presentation: ミッドランドホール 名古屋市
  • Year and Date: 2013-02-09
• [Presentation] DETECTION OF THE THORACIC AORTIC PROSTHETIC GRAFT INFECTION BY FDG-PET/CT (2012)
  • Author(s): Yoshiyuki Tokuda, Masato Mutsuga, Yoshimori Araki, Yuji Narita, Hideki Oshima, Akihiko Usui
  • Organizer: October 30, 2012, Barcelona.26th EACTS European Association for Cardio-Thoracic Surgery
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20121027-31
• [Presentation] FDG-PET/CT による人工血管感染の診断 (2012)
  • Author(s): 徳田順之, 碓氷 章彦, 六鹿雅登, 荒木善盛, 成田裕司, 大島英揮, 古森公浩, 上田裕一
  • Organizer: 第42回日本心臓血管外科学会
  • Place of Presentation: 秋田アトリオン, 秋田キャッスルホテル 秋田市
  • Year and Date: 2012-04-19