2013 Fiscal Year Final Research Report
The mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation
| Project/Area Number |
24791461
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肺移植 / 虚血再灌流障害 / 急性拒絶反応 / 免疫寛容 |
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| Research Abstract |
Outcomes after lung transplantation remain significantly worse than those after transplantation of other solid organs. Ischemia reperfusion injury is the leading cause for early morbidity and mortality after lung transplantation and has also been shown to be a risk factor for chronic lung rejection demonstrating its long-term effect on allografts. In this study, we examined the mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation.
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