Explication of the role of the Bone Morphogenetic Protein (BMP) in lung cancer progression

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Kagoshima University
• Principal Investigator: AOKI Masaya 鹿児島大学, 医歯(薬)学総合研究科, 助教 (50624996)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: BMP-7と予後との関連 / BMP-7とリンパ節転移との関連 / BMP-7とpSmad1/5/8との予後との関連

Outline of Final Research Achievements

We evaluated expression of BMP-7 in non-small cell lung cancer (NSCLC) tissue by immunohistochemistry, and analyzed correlations between expression of BMP-7 and clinicopathological factors and prognosis. The results of this study showed that expression of BMP-7 in NSCLC was correlated with clinicopathological factors and poorer prognosis. We reported these results both in national and international academic meetings and submitted to English journals. Moreover, we evaluated and analyzed expression of p-Smad1/5/8, which is a downstream molecule of the BMP/Smad signaling pathway, in the same way. The results of this study demonstrated that, although expression of p-Smad1/5/8 in NSCLC was not correlated with clinicopathological factors, overexpression of both BMP-7 and p-Smad1/5/8 was correlated with better prognosis. We reported these results in a national academic meeting.

Free Research Field

呼吸器外科