2014 Fiscal Year Final Research Report
Molecular analysis of lung cancer stem cell related gene, SMCP
| Project/Area Number |
24791467
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肺がん / がん幹細胞 |
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| Outline of Final Research Achievements |
We isolated lung cancer stem-like cells(CSCs)/cancer-initiating cells(CICs) by side population assay. Transcriptome anslysis revealed that a novel cancer-testis gene SMCP is preferentially expressed in lung CSCs/CICs. Gene overexpression and gene knockdown assay using siRNAs revealed that SMCP has a role in the tumorigenicity of lung CSCs/CICs. These observations indicate that novel cancer testis gene SMCP might be a promising target for CSC/CIC-targeting therapy.
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| Free Research Field |
腫瘍学
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