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2013 Fiscal Year Final Research Report

Establishment of lung cancer cell line harboring acquired resistance to receptor tyrosine kinase inhibitor

Research Project

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Project/Area Number 24791482
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research InstitutionNagoya University

Principal Investigator

FUKUI Takayuki  名古屋大学, 医学部附属病院, 病院助教 (70463198)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords細胞株 / 肺癌 / 中皮腫 / 胸腺腫
Research Abstract

We started primary culture using surgical specimens or pleural effusions from the patients with malignant tumors treated in Nagoya University. We could get surgical specimens from 20 patients in two years and succeeded in the establishment of the cell lines from a mesothelioma and 3 thymic tumor cases. However, We can not able to establish a cell line harboring acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) which I planned since we could not get the specimens from the patients who were resistant to EGFR-TKI. Thus, we could not able to analyze any gene alterations associated with the EGFR gene using those cell lines. However, several cell lines from mesothelioma and thymoma was successfully primary cultured and established. The cell lines from thoracic malignant tumors except the lung cancer was relatively rare and we performed immunostaining or the graft making with the mouse and confirmed the establishment of the cell lines.

  • Research Products

    (5 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] FDG PET/CT is useful for detecting infiltration to the port site in patients with malignant pleural mesothelioma2014

    • Author(s)
      Kawaguchi K, Taniguchi T, Usami N, Fukui T, Ishiguro F, Nakamura S, Yokoi K
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: 62 Pages: 157-162

    • DOI

      10.1007/s11748-013-0345-y

    • Peer Reviewed
  • [Journal Article] Spontaneous regression of thymic epithelial tumours2013

    • Author(s)
      Fukui T, Taniguchi T, Kawaguchi K, Yokoi K
    • Journal Title

      Interact Cardiovasc Thorac Surg

      Volume: 18 Pages: 399-401

    • Peer Reviewed
  • [Journal Article] Clinicoradiologic characteristics of patients with lung adenoarcinoma harboring EML4-ALK fusion oncogene2013

    • Author(s)
      Fukui T, Yatabe Y, Kobayashi Y, Tomizawa K, Ito S, Hatooka S, Matsuo K, Mitsudomi T
    • Journal Title

      Lung Cancer

      Volume: 77 Pages: 319-325

    • DOI

      10.1016/j.lungcan.2012.03.013

    • Peer Reviewed
  • [Presentation] 胸腺腫細胞株樹立の試み2014

    • Author(s)
      石黒太志, 谷口哲郎, 宇佐美範恭, 川口晃司, 福井高幸, 中村彰太, 尾関直樹, 加藤毅人, 山谷千尋, 横井香平
    • Organizer
      第33回日本胸腺研究会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-02-08
  • [Presentation] A Comparison of Clinicopathologic Features and Survival Outcomes between the Lung Cancer Patients with Adenocarcinoma and Squamous Cell Carcinoma : Stage I Disease of Squamous Cell Carcinoma is there?2013

    • Author(s)
      T. Fukui, Y. Sakao, T. Taniguchi, N. Usami, K. Kawaguchi, F. Ishiguro, S. Nakamura, K. Yokoi
    • Organizer
      15th World Conference on Lung Cancer
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2013-10-28

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Published: 2015-06-25  

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