2014 Fiscal Year Final Research Report
The role of cysteinyl leukotrienes in thrombosis
| Project/Area Number |
24791489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITO Akihiro 東京大学, 医学部附属病院, 助教 (10609598)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | システイニルロイコトリエン / 血小板凝集 |
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| Outline of Final Research Achievements |
Cysteinyl leukotrienes are a family of lipid mediators synthesized from arachidonic acid through the 5-lipoxygenase pathway. We demonstrated that leukotriene C4 (LTC4) were potent to inducer of murine platelet aggregation and clarify their potential roles in the pathogenesis of cardiovascular/cerebrovascular disease using the in vivo thrombosis model with knockout mouse of the receptor of CysLTs.
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| Free Research Field |
脳血管障害
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