Establishment of measuring system of proteomic using cerebrospinal fluid and genetic analysis in patients with moyamoya disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791496
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Nagoya University (2013-2014); Kyoto University (2012)
• Principal Investigator: ARAKI YOSHIO 名古屋大学, 医学部附属病院, 病院助教 (80467290)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: もやもや病 / 脳脊髄液 / タンパク解析 / 遺伝子解析

Outline of Final Research Achievements

In our biomarker research study for MMD, the 4473Da peptide is supposed to be a reliable biomarker of MMD. The higher 4473Da peptide peaks in younger MMD patients are proved to be highly associated with postoperative angiogenesis (Maruwaka M, J Stroke and Cerebrovasc Dis.2015). This research was unfortunately unsuccessful to establish a quantitative assessment system of biomarker using ELISA. On the other hand, genetic analysis of vessel samples showed mutation in RNF 213 related pathway.

Free Research Field

脳神経外科学