2013 Fiscal Year Final Research Report
New therapy for spinal cord injury focused on spinal anterior horn cell
| Project/Area Number |
24791498
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
ISHIHARA Masahiro 大阪大学, 医学(系)研究科(研究院), 研究員 (00533803)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脊髄損傷 / 廃用萎縮 / 脊髄前角神経 |
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| Research Abstract |
Spinal cord injury is often followed by disuse muscle atrophy. The effect of disuse muscle atrophy on motor neurons below the level of spinal cord lesions is not fully understood. Alpha-motor neurons in L4/5 at 3 weeks postinjury showed signs of degeneration associated with disuse muscle atrophy. Muscle atrophy alone did not produce a significant alpha-motor neuronal degeneration.
Our results demonstrated GDNF was responsible for alpha-motor neuronal degeneration with disuse muscle atrophy and GDNF injection in muscle could prevent alpha-motor neuronal degeneration.
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