2014 Fiscal Year Final Research Report
Identification of molecular targets for malignant glioma stem cells and stem cell niche.
| Project/Area Number |
24791499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
KIJIMA Noriyuki 大阪大学, 医学(系)研究科(研究院), 特任研究員 (80534627)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | グリオーマ幹細胞 / 幹細胞niche / ALCAM |
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| Outline of Final Research Achievements |
In this research project, we examined the functional roles of CD166/activated leukocyte cell adhesion molecule (ALCAM) in glioblastoma. We found that ALCAM is involved in glioblastoma angiogenesis through VEGF independent mechanism.
Our results suggest that ALCAM could be a new anti-angiogeneic agent in glioblastoma.
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| Free Research Field |
脳神経外科学
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