Epigenetic subclassification and molecular biological research on malignant subgroups of meningiomas

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791514
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Fukushima Medical University
• Principal Investigator: KISHIDA YUGO 福島県立医科大学, 医学部, 講師 (00467292)
• Co-Investigator(Kenkyū-buntansha): WADA Ikuo 福島県立医科大学, 細胞科学, 教授 (40182969) ; INOUE Naokazu 福島県立医科大学, 細胞科学, 准教授 (50379096)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 髄膜腫 / DNAメチル化 / 悪性転化

Outline of Final Research Achievements

Some populations of meningiomas show malignant clinical behavior in despite of benign histological diagnosis.In this study, novel diagnostic criteria other than histological classification to determine malignant subgroup of meningiomas is presented. A subgroup of meningiomas is characterized by aberrant hypermethylation of the subset of genes in the early stage of tumorigenesis, and our findings highlight the possibility of speculating potential malignancy of meningiomas by assessing methylation status. On the other hand, molecular biological studies about function of hypermethylated genes didn’t show reproducible results. Fukushima medical university brain tumor tissue bank established for basic research has collected over 250 cases of intracranial tumors.

Free Research Field

脳腫瘍のエピジェネティクス