11C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791520
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: National Hospital Organization Osaka National Hospital Institute for Clinical Reserch (2013-2014); Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012)
• Principal Investigator: OKITA Yoshiko 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 (10533797)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: glioma / MET-PET / MGMT

Outline of Final Research Achievements

Several studies have aimed to detect biomarkers in glioma using noninvasive imaging techniques. This study examines the correlation between 11C-methionine uptake and MGMT promoter methylation in grade Ⅱ and grade Ⅲ nonenhancing gliomas.Data was collected from 20 patients with grade Ⅱ and Ⅲ nonenhancing gliomas who underwent both MRI and 11C-methionine PET as part of their pre-surgical examination. We examined MGMT promoter methylation by quantitative methylation-specific PCR.The mean MGMT promoter methylation for tumors with T/N ratios ≧1.6 was 28.0 ± 26.3, and that for tumors with T/N ratios <1.6 was 0.68 ± 0.89. The MGMT promoter methylation for tumors with T/N ratios ≧1.6 was significantly higher than that for tumors with T/N ratios <1.6 (P < 0.05).A higher uptake in 11C-methionine PET may reflect increased MGMT promoter methylation. 11C-methionine PET could be a useful tool to detect MGMT promoter methylation in nonenhancing glioma.

Free Research Field

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