Registry study for clinical and radiological features of cerebral venous thrombosis in Japan

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: Kyoto Prefectural University of Medicine (2014); National Cardiovascular Center Research Institute (2012-2013)
• Principal Investigator: OHARA Tomoyuki 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20616388)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳静脈血栓症 / T2*強調画像 / 抗凝固療法 / 血管内治療

Outline of Final Research Achievements

Clinical and radiological features of cerebral venous thrombosis (CVT) in Japan were analyzed based on 33 patients data retrospectively. Compared to data from western countries, hematological condition, polycythemia and anemia, as well as thrombophilia were more frequent causes of CVT in our study. The main problem in the management of CVT was diagnostic delay, which occurred in one-third of all cases. Our results suggested T2* weighted MR imaging were most helpful for early diagnosis of CVT. Almost all patients received anticoagulant therapy in acute phase, but neurological worsening mainly caused by hematoma expansion was often observed in patients with intracranial hemorrhage on admission. Neurological worsening was associated with poor outcome. Therefore, it is essential to establish more effective therapeutic strategy for CVT including early intervention of endovascular therapy. We need to confirm clinical problems identified in our ongoing CVT registry.

Free Research Field

医学　脳卒中学