Development of porous/dense composite polyurethane scaffold for bone tissue repair

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791526
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YOSHII Toshitaka 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (50583754)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ポリウレタン / scaffold / 骨再生

Outline of Final Research Achievements

The efficacy of polyurethane (PUR) scaffold has been reported as a scaffold in bone tissue engineering. To improve mechanical strength of PUR scaffold, we have added calcium phosphate (CaP) to resin component before polymerization. The mechanical property of PUR-CaP and in vitro osteoconductivity were evaluated. Favorable mechanical strength was obtained by adding 70 and 79 weight % of CaP. In vitro preosteoblast culture showed good proliferation and osteogenic differentiation of the cells on the PUR/CaP. Furthermore, we made hollow-shaped PUR/HA combined with highly porous PUR. The metical property of this composite PUR was evaluated. In vivo osteoconductivity of the composite PUR was examined in rat bone defect model.

Free Research Field

整形外科学