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2013 Fiscal Year Final Research Report

Development of novel treatment of rheumatoid arthritis by regulation of adiponectin

Research Project

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Project/Area Number 24791542
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

EBINA Kosuke  大阪大学, 医学(系)研究科(研究院), 助教 (70612076)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsアディポネクチン / 関節リウマチ
Research Abstract

We established 300 RA patients clinical database including severity and extent of joint destruction. We have previously reported that severity of RA evaluated by the extent of joint destruction is associated with serum adiponectin (APN)levels. In addition, APN and complement C1q forms complex (APN-C1q) in human serum and associate with the risk of cardiovascular events of type2 diabetes. From our results, serum APN-C1q levels of RA patients were significantly higher than that of age-and-BMI matched controls, and also showed stronger correlation with severity and extent of joint destruction compared to serum APN and C1q levels, respectively. Monitoring serum APN-C1q levels may be a novel predictive factor and of RA joint destruction and its clinical application as treatment target is expected.

  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 11;111(10) Pages: 3787-92

    • Peer Reviewed
  • [Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice2013

    • Author(s)
      Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H
    • Journal Title

      PLoS One

      Volume: 5;8(6) Pages: e65339

    • Peer Reviewed
  • [Journal Article] IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro2013

    • Author(s)
      Kaneshiro S, Ebina K, Shi K, Hirao M, Hashimoto J, Morimoto T, Koizumi K, Yoshikawa H.
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis2013

    • Author(s)
      Ebina K, Shi K, Hirao M, Kaneshiro K, Morimoto T, Koizumi K, Yoshikawa K, Hashimoto J
    • Journal Title

      ModRheumatol

      Volume: 23(5) Pages: 1001-7

    • Peer Reviewed
  • [Journal Article] Retention of Tocilizumab and Anti-Tumor Necrosis Factor Drugs in the Treatment of Rheumatoid Arthritis2013

    • Author(s)
      Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K., et al
    • Journal Title

      Scand J Rheumatol

      Volume: 42(4) Pages: 253-9

    • Peer Reviewed
  • [Journal Article] Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis2013

    • Author(s)
      Nampei A, Shi K, Ebina K, Tomita T, Sugamoto K, Yoshikawa H, Hirao M, Hashimoto J
    • Journal Title

      J Clin Biochem Nutr

      Volume: 52(2) Pages: 179-84

    • Peer Reviewed
  • [Journal Article] Use of a custom-made surgical guide in total ankle arthroplasty in rheumatoid arthritis cases2013

    • Author(s)
      Hirao M, Oka K, Ikemoto S, Nakao R, Tsuboi H, Nampei A, Akita S, Shi K, Ebina K, et al
    • Journal Title

      Techniques in Orhopaedics

      Volume: (under publish)

    • Peer Reviewed
  • [Journal Article] Nkx3.2 promotes primary chondrogenic differentiation by upregulating col2a1 transcription2012

    • Author(s)
      Kawato Y, Hirao M, Ebina K, Shi K, Hashimoto J, Honjo Y, Yoshikawa H, Myoui A.
    • Journal Title

      PLoS One

      Volume: 7(4) Pages: e34703

    • Peer Reviewed
  • [Journal Article] Hypoxia favors maintenance of the vascular smooth muscle cell phenotype in culture2012

    • Author(s)
      Yamasaki N, Hirao M, Kawato Y, Ebina K, Oze H, Nampei A, Shi K, Yoshikawa H, Hashimoto J
    • Journal Title

      J Biochem Mol Toxicol

      Volume: 26(10) Pages: 381-3

    • Peer Reviewed
  • [Journal Article] Impact of medium volume and oxygen concentration in the incubator on pericellular oxygen concentration and differentiation of murine chondrogenic cell culture2012

    • Author(s)
      Oze H, Hirao M, Ebina K, Shi K, Kawato Y, Kaneshiro S, Yoshikawa H, Hashimoto J.
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 48(2) Pages: 123-30

    • Peer Reviewed
  • [Presentation] 脂質運搬蛋白ApolipoproteinE ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第87回日本整形外科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20140500
  • [Presentation] 成長因子Progranulin ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第87回日本整形外科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20140500
  • [Presentation] 脂肪細胞分泌因子アディポネクチン(APN)と補体C1q の複合体(APN-C1q)の血中濃度は非RA 患者よりRA 患者で有意に高値でありかつ破壊関節数による重症度と相関する2014

    • Author(s)
      蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第58回日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20140400
  • [Presentation] 成長因子Progranulin ノックアウトマウスは重度の骨粗鬆症を呈する2014

    • Author(s)
      野口貴明, 蛯名耕介, 史賢林, 吉川秀樹
    • Organizer
      第58回日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20140400
  • [Book] 臨床リウマチ25巻1号2013

    • Author(s)
      蛯名耕介
    • Total Pages
      14-19

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Published: 2015-06-25  

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