2013 Fiscal Year Final Research Report
Development of novel treatment of rheumatoid arthritis by regulation of adiponectin
| Project/Area Number |
24791542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
EBINA Kosuke 大阪大学, 医学(系)研究科(研究院), 助教 (70612076)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アディポネクチン / 関節リウマチ |
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| Research Abstract |
We established 300 RA patients clinical database including severity and extent of joint destruction. We have previously reported that severity of RA evaluated by the extent of joint destruction is associated with serum adiponectin (APN)levels. In addition, APN and complement C1q forms complex (APN-C1q) in human serum and associate with the risk of cardiovascular events of type2 diabetes. From our results, serum APN-C1q levels of RA patients were significantly higher than that of age-and-BMI matched controls, and also showed stronger correlation with severity and extent of joint destruction compared to serum APN and C1q levels, respectively. Monitoring serum APN-C1q levels may be a novel predictive factor and of RA joint destruction and its clinical application as treatment target is expected.
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Research Products
(15 results)
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[Journal Article] Oxygen and air nanobubble water solution promote the growth of plants, fishes, and mice2013
Author(s)
Ebina K, Shi K, Hirao M, Hashimoto J, Kawato Y, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H
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Journal Title
PLoS One
Volume: 5;8(6)
Pages: e65339
Peer Reviewed
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