2013 Fiscal Year Final Research Report
The role of bone marrow adipose tissue on the proliferation, differentiation, and lipotoxicity of osteoblasts
| Project/Area Number |
24791553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 骨粗鬆症 / 脂肪毒性 / 骨芽細胞 / 骨細胞 / 脂肪組織 |
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| Research Abstract |
We established a novel cell culture system, which reproduced the transition process from osteoblast to osteocyte. Using this model, we examined the effect of adipose tissue on osteoblasts/osteocytes, and found that 1) adipose tissue inhibit the proliferation and differentiation of osteoblasts by soluble factors, 2) osteocytes were more insensitive to adipose tissue than osteoblasts, and 3) no different effect was observed between subcutaneous and epididymal adipose tissues. These suppressive effects may be involved in the regulatory mechanisms of bone homeostasis.
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