2013 Fiscal Year Final Research Report
MicroRNAs regulate cancer bone metastasis via exosomes.
| Project/Area Number |
24791567
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
TAKEDA Shu 東京医科歯科大学, 大学院, 教授 (30376727)
FUKUDA Toru 東京医科歯科大学, 大学院, 助教 (20301492)
OCHI Hiroki 日本獣医生命科学大学, 獣医学部, 助教 (30582283)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 癌 / 骨転移 / マイクロRNA / 骨代謝 |
|---|
| Research Abstract |
A microRNA is a small non cording RNA molecule which functions in transcriptional and post-transcriptional regulation of gene expression. Exosomes are small vesicles that can function as intercellular transmitters to convey their contents, in particular, miRNAs.
In this study, we focused on human prostate cancer. Prostate cancer is known to induce osteoblastic responses when it harbors at the bone marrow space. We identified microRNAs that secreted by human prostate cancer cells. Overexpression of some of these miRNAs in osteoblastic cells led to increase alkaline phosphatase activity. We try to reveal the target gene of these miRNAs and the mechanism of bone metastasis regulated by miRNAs.
|
