2013 Fiscal Year Final Research Report
Electrophysiological analysis of anesthetic neuroprotective effect
| Project/Area Number |
24791582
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
HONDA Hiroyuki 新潟大学, 医歯学総合病院, 講師 (20535174)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経保護 / 脊髄虚血 / パッチクランプ / 興奮性神経細胞死 |
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| Research Abstract |
One of the most worrisome complications of thoracoabdominal aneurysm repair is paraplegia caused by spinal cord ischemia. We revealed that ischemic insult induced the three-phase change of synaptic neurotransmission on spinal ventral horn neurons. The reactive oxygen species also produced similar reaction. We also elucidated that mu opioid receptor activation inhibited both the excitatory and inhibitory neurotransmission in spinal ventral horn neurons but did not influence ongoing ischemia-induced neuronal death. Our findings suggest that control of the inhibitory input to the spinal ventral horn neurons is important for neuroprotection.
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