2013 Fiscal Year Final Research Report
Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow
| Project/Area Number |
24791587
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
ISHIDA Takashi 信州大学, 医学部附属病院, 医員 (60531952)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 痛み / 骨 / オピオイド / 脊髄 |
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| Research Abstract |
We recorded 43 SDH neurons sensitive to balloon inflation in the medullary cavity. Most of the SDH neurons had somatic receptive field at the lower back and the lateral part of thigh. Thirty-two of the SDH neurons were WDR neurons and 11 of the SDH neurons were HT neurons. There were no LT neurons in the 43 SDH neurons tested. Spinally administered morphine (1 microg) did not suppress the responses of the SDH neurons to brush and 4-g von Frey filament but those to pinch and balloon inflation in the medullary cavity. The results suggest that nerve fibers in the medullary cavity sense noxious stimulation and send the signals to SDH. Bone marrow afferent input converges onto the SDH neurons responding to somatic mechanical stimuli. The results supported the concept that activation of bone marrow afferent might lead to the production of referred pain in somatic fields.
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