2013 Fiscal Year Final Research Report
The mechanism of insulin resistance induced by the drugs on the perioperative period
| Project/Area Number |
24791603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
YONAHA Tetsu 宮崎大学, 医学部, 助教 (70468023)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | グルコース / インスリン抵抗性 |
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| Research Abstract |
Glucose metabolic rate was decreased in sevoflurane treated murine fibroblast-derived adipocytes (3T3L1), suggesting suppressed glucose uptake. In addition, sevoflurane may suppress the translocation of glucose transporter GLUT4 to the cell membrane 3T3L1. Further, the increase of insulin receptor protein, decrease of PKC zeta protein was observed in sevoflurane treated 3T3L1, and are involved in protein expression of pathways involved in glucose transport was suggested.
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