Investigation about the sex differences and postoperative nausea and vomiting using epigenome-wide association study.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Sapporo Medical University
• Principal Investigator: Hayase Tomo 札幌医科大学, 医学部, 助教 (20579007)
• Co-Investigator(Renkei-kenkyūsha): YAMAKAGE MICHIAKI 札幌医科大学, 医学部, 教授 (70285005)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 性差

Outline of Final Research Achievements

We investigated whether single nucleotide polymorphisms (SNPs) of the TACR1 gene are associated with postoperative nausea and vomiting (PONV). We found that an SNP within the estrogen response element of the TACR1 gene was strongly associated with decreased frequency of PONV occurrence. Haplotype analysis revealed that patients with a specific haplotype showed lower frequency of PONV occurrence and PONV of less intensity. To determine the association between estrogen and PONV occurrence, we analyzed the methylation rate of the promoter region of the TACR1 gene in humans and investigated whether estrogen promotes the pica behavior in operation model mice. In humans, the intensity of PONV was decreased by methylation of the promoter region of the TACR1 gene. In mice, estrogen and mu-opioid additively promoted pica behavior.

Free Research Field

麻酔科学