Relationship between barain serotonin and abnormal behavior-Trial of the preventional method against serotonin syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791618
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka City University
• Principal Investigator: TAKAHASHI Ryota 大阪市立大学, 医学(系)研究科(研究院), 講師 (00464628)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: セロトニン症候群 / トラマドール / 痙攣 / 脳内モノアミン

Outline of Final Research Achievements

Tramadol has a multitude of pharmacological properties, acting as an agonist at opioid receptors, while inhibiting reuptake of serotonin and noradrenaline. Combination therapy of tramadol and tricyclic antidepressant may increase serotonin syndrome. Continuous intravenous injection of tramadol resulted in marked increases serotonin concentration in the hypothalamus and induced seizure. Here, we investigated the relationship between serotonin and the seizure-inducing potential of tramadol. Pretreatment significantly affected seizure threshold and serotonin fluctuations. The threshold was lowered in serotonin decreased group and raised in serotonin increased group. So we indicated that tramadol-induced seizures are distinct from serotonin syndrome.

Free Research Field

神経科学