Mechanisms of lipid infusion on local anesthetic-induced cardiac toxicity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791619
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka City University
• Principal Investigator: MATSUURA Tadashi 大阪市立大学, 医学(系)研究科(研究院), 講師 (90619793)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 局所麻酔薬中毒 / 脂肪乳剤 / パッチクランプ / ランゲンドルフ

Outline of Final Research Achievements

Lipid emulsion has been reported to be quite effective against local anesthetic-induced systemic toxicity. This study aimed to investigate the mechanisms of lipid infusion therapy. Proton channels recordings by patch-clamp method revealed that extracellular lipid emulsion trapped bupivacaine to decrease the concentration of extracellular bupivacaine and consequently the intracellular concentration of bupivacaine was decreased. This result supports the importance of "lipid sink" of lipid infusion therapy. Both results of lagendorff experiments and in vivo experiments could also suggest that "lipid sink" is the main mechanism of lipid infusion therapy.

Free Research Field

麻酔科学