2014 Fiscal Year Final Research Report
The role of axonal transport on neuropathic pain
| Project/Area Number |
24791624
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kitasato University |
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Principal Investigator |
ISONAKA Risa 北里大学, 医学部, 講師 (50550547)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 軸索輸送 / 神経因性疼痛 |
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| Outline of Final Research Achievements |
Chronic pain is difficult to ameliorate and results in reduced quality of life for suffering individuals. Analgesics play an important role in the clinical management of chronic pain. I reported on the effects of the analgesic agent neurotropin on axonal transport in cultured mouse dorsal root ganglion neurons. Neurotropin, used extensively in Asia to treat various chronic pains, significantly inhibited axonal transport without affecting the diameter of neurites. To our knowledge, this is the first study that demonstrated the effect of neurotropin on sensory neurons, and our findings elucidated the analgesic mechanisms of neurotropin (Neurosci Lett 2013).
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| Free Research Field |
生理学
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