2013 Fiscal Year Final Research Report
Mechanism of prophylactic effect of valproate for postoperative pain
| Project/Area Number |
24791626
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HOBO Shotaro 東京慈恵会医科大学, 医学部, 助教 (60385359)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 疼痛管理学 |
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| Research Abstract |
Repeated oral administration of valproate prevented the development of hypersensitivity in rats after peripheral nerve injury. Intrathecal injection of the selective GLT-1 blocker dihydrokainic acid DHK blocked the effect. This result suggests that valproate prevents the development of chronic pain after peripheral nerve injury in spinal cord in part by preventing downregulation of glutamate transporters. In clinic, we experienced two cases of successful combination therapy by valproate and pregabalin in chronic pain patients. No significant adverse effects are confirmed in the combination therapy. In future, we proceed to the further research to test whether perioperative use of the combination prevents chronic pain after surgery.
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