2014 Fiscal Year Final Research Report
Mulutiple analysis of miRNA under neuropathic pain
| Project/Area Number |
24791627
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | miRNA / pain / epigentic |
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| Outline of Final Research Achievements |
In this study, we focused on the expression change of microRNA(miRNA) under neuropathic pain. The aim of these studies was to clarify the molecular mechanism of chronic pain and to explore the biomarkers of neuropathic pain. Using neuropathic pain model, we were able to profile the expression miRNA in amygdala, nucleus accumbens, prefrontal cortex, spinal cord and serum under neuropathic pain. Furthermore, we identified the change in the serum miRNA in human chronic pain patient. These result suggest that blood miRNA has the potential as a biomarker for neuropathic pain. These research results were published in Trends Neurosci, 38, 237-246, 2015 (IF:12.902), Brain, 136, 828-843, 2013 (IF; 9.457) etc.
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| Free Research Field |
神経科学
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