2013 Fiscal Year Final Research Report

Effect of general anesthetic on central nervous system of neonatal marmoset

Research Project

Project/Area Number	24791630
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology/Resuscitation studies
Research Institution	独立行政法人国立精神・神経医療研究センター
Principal Investigator	MIYAJIMA Moeko 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 客員研究員 (90318147)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	全身麻酔 / 幼弱期暴露 / 障害 / 霊長類
Research Abstract	Recently it was reported that children who received general anesthesia repeatedly before 4 years were at significantly increased risk of learning disability. Many animal studies have shown that commonly used anesthetic agents have a neurotoxic effect on the developing brain. The purpose of this study is to examine whether general anesthetic causes neuroapoptosis in neonatal marmosets. We observed increased apoptosis not only in the cortex but also in the white matter.