2014 Fiscal Year Final Research Report
Basic research for the autologous cancer vaccination- and radiation-combined therapy for urogenital cancers.
| Project/Area Number |
24791650
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 前立腺癌 / 放射線治療 / ワクチン / 注入法 |
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| Outline of Final Research Achievements |
The first in-human clinical study, a Phase I/IIa study of in situ Ad-REIC gene therapy for prostate cancer, is currently performed in our department. Using the Ad-REIC as a new form of therapeutic cancer vaccine, the effects of autologous cancer vaccination via cancer-specific apoptosis and anticancer immune upregulation is evaluated as the therapeutic mechanism. On the other hands, the combination therapy with radiation and Ad-REIC agent could be promising for the treatment of progressive urogenital cancers. We herein conducted a basic research for the development of novel therapeutic methods. In addition, we performed the experiments as for a novel method for achieving widespread intratissue distribution of the infusate by permeating it in situ.
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| Free Research Field |
医歯薬学
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