2013 Fiscal Year Final Research Report
Mechanism of resistance to tyrosine-kinase inhibitor in renal cell carcinoma
| Project/Area Number |
24791654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 腎細胞癌 / 血管新生 / チロシンキナーゼ阻害剤 / 耐性 |
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| Research Abstract |
Hyperangiogenesis has not been a role of resistance to tyrosine-kinase inhibitor in renal cell carcinoma. Cross-talk with Hyperangiogenesis and microenvironment might be a key mechanism of resistance to tyrosine-kinase inhibitor in renal cell carcinoma. The resistance has been reversible reaction.
Thus, novel therapeutic strategies are really needed for resolving resistance to tyrosine-kinase inhibitor such as approaching to tumor-microenvironment and combination therapy with others.
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