2013 Fiscal Year Final Research Report
GPX2 overexpression is involved in cell proliferation and prognosis of castration resistant prostate cancer
Project/Area Number |
24791658
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Nagoya City University |
Principal Investigator |
NAIKI Taku 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50551272)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 去勢抵抗性前立腺癌 / 酸化ストレス / Glutathione peroxidase 2 / 動物モデル |
Research Abstract |
Prostate cancer generally acquires castration-resistant growth capacity with progression, resulting in resistance to anti-androgen therapy. Therefore, identification of genes that are regulated through this process may be important. We previously established a new castration-resistant prostate cancer (CRPC) metastatic model. We found that the glutathione peroxidase 2 (GPX2) gene was overexpressed in CRPC model, and we presented novel data showing that silencing of GPX2 by siRNA caused significant growth inhibition, and increased intracellular ROS in CRPC. Analyses of prostatectomy specimens demonstrated that GPX2 expression was significantly higher in residual cancer foci after hormone therapy than in hormone naive cancer foci. Moreover, patients with highly expressed GPX2 in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those negative for GPX2. These findings suggest that GPX2 may be therapeutic target for CRPC.
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[Journal Article] GPX2 is involved in cell proliferation in castration resistant prostate cancer2014
Author(s)
Naiki T, Naiki-Ito A, Asamoto M, Kawai N, Tozawa K, Etani T, Sato S, Suzuki S, Shirai T, Kohri K, Takahashi S
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Journal Title
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[Presentation] Glutathione peroxidase 2 is a potential therapeutic molecule for castration-resistant prostate cancer2013
Author(s)
Naiki T, Asamoto M, Naiki-Ito A, Kawai N, Tozawa K, Ando R, Etani T, Ikegami Y, Naruyama Y, Fukuta K, Hashimoto Y, Akita H, Nagata D, Yamada K, Okamura T, Takahashi S, Kohri K
Organizer
AUA annual meetings
Place of Presentation
SanDiego, USA
Year and Date
20130504-08
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