Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791661
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: YANAI Yoshimasa 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (40468252)
• Research Collaborator: FUJUI Yasuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (30566229)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メタボリックシンドローム / 腎結石 / アディポネクチン

Outline of Final Research Achievements

Wild-type (+/+) mice showed no kidney crystal formation, whereas ob/ob mice showed crystal depositions in their renal tubules. Expression analysis of genes associated with MetS-related kidney crystal formation identified 259 genes that were >2.0-fold up-regulated and 243 genes that were <0.5-fold down-regulated. Gene Ontology (GO) analyses revealed that the up-regulated genes belonged to the categories of immunoreaction, inflammation, and adhesion molecules and that the down-regulated genes belonged to the categories of oxidative stress and lipid metabolism. Expression analysis of adiponectin-induced genes related to crystal prevention revealed that the numbers of up- and down-regulated genes were 154 and 190, respectively. GO analyses indicated that the up-regulated genes belonged to the categories of cellular and mitochondrial repair, whereas the down-regulated genes belonged to the categories of immune and inflammatory reactions and apoptosis.

Free Research Field

腎・泌尿器科学分野